- HOME
- Stabilized Oil Soluble Vitamin C with Comprehensive Efficacy - NIKKOL VC-IPVS
Stabilized Oil Soluble Vitamin C with Comprehensive Efficacy
- NIKKOL VC-IPVS
HISTORY
NIKKOL GROUP pioneered the commercialization of an oil-soluble version of a vitamin C derivative in 1961. Utilizing its expertise on colloid dermatological science, NIKKOL VC-IP was designed as an ester for high stability during processing and with high percutaneous absorption on skin versus water-soluble derivatives.
After 25 years, we have developed NIKKOL VC-IPVS, a natural grade derived from responsibly-sourced palm ingredients; it is also vegan-friendly and HALAL-certified (MPJA).
Timeline
- 1961
- Developed and launched lipophilic Vitamin C derivative. (World’s 1st)
- 1986
- NIKKOL VC-PMG was launched as novel quasi-drug whitening active.
- 1997
- NIKKOL VC-IP was released.
- 2009
- NIKKOL VC-IPEX obtained QD whitening active status in Japan.
- 2010
- NIKKOL VC-IP obtained functional ingredient for skin lightening in South Korea.
- 2022
- NIKKOL VC-IPVS was launched.
PROVEN EFFICACY

Click to open E-book which contains NIKKOL VC-IP’s efficacy data and expertise of formulating tips.
*Membership registration is required to open E-book.
Quick trial member and full member cannot use this function.
Papers
- · A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties
-
Yasunobu Ochiai 1, Satoko Kaburagi, Kei Obayashi, Nobuyuki Ujiie, Satoru Hashimoto, Yuri Okano, Hitoshi Masaki, Masamitsu Ichihashi, Hiromu Sakurai
Journal of Dermatological Science, 28 Aug 2006, 44(1):37-44 - · Effect of a new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), on senile lentigo via controlling melanocytes-keratinocytes interaction.
-
Mariko Yokota
Presented at IFSCC conference 2017 - · Improvement of Hair Damage by Lipophilic Vitamin C (Ascorbyl Tetraisopalmitate)
-
Takeshi Misono, Shunsuke Yanaguchi, Satoru Hashimoto
Journal of SCCJ, 2018, 52(3), 205-209 - · Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopaimitoyl ascorbic acid
-
Mariko Yokota, Shoichi Yahagi
J Cosmet Dermatol, 2021;00:1-12
SUSTAINABILITY
NIKKOL VC-IP is primarily manufactured at Nippon Surfactant Industries in Utsunomiya city in Japan. This factory is famous for its eco-friendly, sustainable policies through these local & globally-recognized certifications or activities.
- 1.
- Engages in Eco Action 21 since 2012 - a certifying body authorized by Japan’s Ministry of Environment that promotes companies to improve their own environmental management systems.
- 2.
- Joined the global RSPO supply chain group in 2018. Currently, the factory produces more than 300 products that are RSPO-MB certified.
- 3.
- Awarded “Silver” in the global sustainability ratings index- EcoVadis every year since 2019.
Carbon conscious processes for NIKKOL VC-IPVS
NIKKOL VC-IP VS is manufactured using a dedicated reactor for Vitamin C derivatives. Several processes are in place to continually reduce carbon emissions from its processing. Specifically, these are the systems involved in the manufacturing of this product:
- 1.
- Utilizing gas co-generation system to generate 2 types of energy- electricity & heat to power reactors and boil water.
- 2.
- Optimizing the esterification process- shortened reaction time.
- 3.
- Re-using stored condensed water from other processes to cool down the reaction.
- 4.
- Recovery and recycling of used organic solvents used in the process.
CO2 emission reduction
*Calculated using the US environmental protection agency greenhouse gas calculator
Chemical-Navi is a free resource for registered members.
Become a Member